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Test your understanding of the contraindications of Human Immunodeficiency Virus (HIV) medications
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Question 1 of 11
1. Question
What is/are the contraindications of entecavir?
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The correct answer is There are no contraindications listed in the manufacturer’s US labeling
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Question 2 of 11
2. Question
What is/are the contraindications of Raltegravir?
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The correct answer is There are no contraindications listed in the manufacturer’s labeling.
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Question 3 of 11
3. Question
What is/are the contraindications of Oseltamivir?
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The correct answer is Hypersensitivity to oseltamivir or any component of the formulation
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Question 4 of 11
4. Question
What is/are the contraindications of maraviroc?
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The correct answer is Patients with severe renal impairment (CrCl <30 mL/minute) or end-stage renal disease (ESRD) who are taking concomitant potent CYP3A inhibitors or inducers
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Question 5 of 11
5. Question
Which of the following is a contraindication of Acyclovir?
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The correct answer is Hypersensitivity to acyclovir, valacyclovir, or any component of the formulation; Hypersensitivity to milk protein concentrate with the buccal tablet
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Question 6 of 11
6. Question
Which of the following is a contraindication of Valacyclovir?
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The correct answer is Hypersensitivity to valacyclovir, acyclovir, or any component of the formulation
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Question 7 of 11
7. Question
Which of the following is a contraindication of Atazanavir?
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The correct answer is Hypersensitivity (eg, Stevens-Johnson syndrome, erythema multiforme, toxic skin eruptions) to atazanavir or any component of the formulation; concurrent therapy with alfuzosin, amiodarone (when atazanavir is coadministered with ritonavir), cisapride, elbasvir/grazoprevir, glecaprevir/pibrentasvir, ergot derivatives (dihydroergotamine, ergonovine, ergotamine, methylergonovine), indinavir, irinotecan, lomitapide, lovastatin, lurasidone (when atazanavir is coadministered with ritonavir), midazolam (oral), nevirapine, pimozide, quinidine (when atazanavir is coadministered with ritonavir), rifampin, sildenafil (when used for pulmonary artery hypertension [eg, Revatio]), simvastatin, St. John’s wort, or triazolam.
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Question 8 of 11
8. Question
Which of the following is a contraindication of Fosamprenavir?
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The correct answer is Clinically significant hypersensitivity (eg, Stevens-Johnson syndrome) to fosamprenavir, amprenavir, or any component of the formulation;coadministration with drugs highly dependent on CYP3A4 for clearance and for which elevated plasma concentrations are associated with serious and/or life-threatening events (eg, alfuzosin, rifampin, ergot derivatives [eg, dihydroergotamine, ergonovine, ergotamine, methylergonovine], cisapride, St. John’s wort, lovastatin, lomitapide, simvastatin, pimozide, delavirdine, sildenafil [when used for treatment of pulmonary arterial hypertension], midazolam, or triazolam);use of flecainide, lurasidone, or propafenone with concomitant ritonavir therapy.
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Question 9 of 11
9. Question
Which of the following is a contraindication of Darunavir?
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The correct answer is Coadministration with drugs that are highly dependent on CYP3A for clearance and drugs for which elevated plasma concentrations are associated with serious and/or life-threatening events (narrow therapeutic index) (eg, alfuzosin, dronedarone, colchicine [in patients with renal and/or hepatic impairment], ranolazine, ergot derivatives [dihydroergotamine, ergonovine, ergotamine, methylergonovine], cisapride, lurasidone, pimozide, midazolam (oral), triazolam, St. John’s wort, elbasvir/grazoprevir, lomitapide, lovastatin, simvastatin, rifampin, sildenafil [for the treatment of pulmonary hypertension], ivabradine, naloxegol). Must be coadministered with ritonavir; refer to individual monograph for ritonavir for additional contraindication information
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Question 10 of 11
10. Question
Which of the following is a contraindication of Efavirenz?
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The correct answer is Hypersensitivity (eg, Stevens-Johnson syndrome, erythema multiforme, toxic skin eruptions) to efavirenz or any component of the formulation; concurrent administration with elbasvir or grazoprevir
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Question 11 of 11
11. Question
Which of the following is a contraindication of Emtricitabine/Tenofovir Disoproxil Fumarate?
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Incorrect
The correct answer is As preexposure prophylaxis in patients with unknown or HIV-1 positive status